Russo Francesco Paolo, Ferrarese Alberto, Zanetto Alberto
Gastroenterology/Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
F1000Res. 2016 Dec 21;5. doi: 10.12688/f1000research.8768.1. eCollection 2016.
Liver transplantation (LT) has been established as the most effective treatment modality for end-stage liver disease over the last few decades. Currently, patient and graft survival after LT are excellent, with 1- and 5-year survival of 90% and 80%, respectively. However, the timing of referral to LT is crucial for improving survival benefit and outcome. The current shortage of donors and the increasing demand for LT currently lengthen the waiting time. Thus, waiting list mortality is about 10-15%, according to the geographical area. For this reason, over the last several years, alternatives to deceased donor LT and new options for prioritizing patients on the waiting list have been proposed.
在过去几十年中，肝移植（LT）已成为治疗终末期肝病最有效的治疗方式。目前，肝移植术后患者和移植物的存活率很高，1年和5年生存率分别为90%和80%。然而，转介进行肝移植的时机对于提高生存获益和治疗结果至关重要。目前供体短缺以及对肝移植需求的增加导致等待时间延长。因此，根据不同地理区域，等待名单上的死亡率约为10%-15%。出于这个原因，在过去几年中，人们提出了已故供体肝移植的替代方案以及在等待名单上对患者进行优先排序的新选择。
