Gemelli Maria Grazia, Yockel Katherine, Hohmeier Kenneth C
Consult Pharm. 2016 Nov 1;31(11):650-657. doi: 10.4140/TCP.n.2016.650.
To determine if pharmacist intervention can decrease the use of inappropriate sedative/hypnotics in the elderly population in the long-term care facility setting.
A multicenter, prospective chart review of sedative/hypnotic use for insomnia among long-term care facility residents.
Eleven regional long-term care facilities in Northeastern Tennessee.
Long-term care facility residents older than 65 years of age, with confirmed insomnia diagnoses and no history of seizure or recent psychotropic gradual-dose reduction attempts.
Consultant pharmacist recommendations to decrease inappropriate use of sedative/hypnotics.
Acceptance rates for discontinuation/tapering of the selected sedative/hypnotics.
A total of 36 patients were enrolled in the study based on inclusion/exclusion criteria. Overall, 39 interventions were performed. Gradual dose reductions/ discontinuation of select sedative/hypnotics were accepted for 19 residents (48.7%). Of the other recommendations, 8 (20.5%) were denied and 12 (30.8%) were left unanswered. Primary reasons for denial included family refusal, satisfactory response to current dose, and requirement of increased dose as a result of worsening insomnia.
Overall, pharmacist intervention can have a meaningful impact on reducing inappropriate sedative/ hypnotic use in the elderly population through concise, evidence-based recommendations to physicians.
确定药剂师的干预措施能否减少长期护理机构中老年人群不适当使用镇静/催眠药物的情况。
对长期护理机构居民中用于治疗失眠的镇静/催眠药物使用情况进行多中心前瞻性图表回顾。
田纳西州东北部的11家地区长期护理机构。
65岁以上的长期护理机构居民,确诊患有失眠症,且无癫痫病史或近期未尝试过精神药物逐渐减量。
顾问药剂师提出减少不适当使用镇静/催眠药物的建议。
所选镇静/催眠药物停药/逐渐减量的接受率。
根据纳入/排除标准,共有36名患者纳入研究。总体而言,共进行了39次干预。19名居民(48.7%)接受了所选镇静/催眠药物的逐渐减量/停药。在其他建议中,8条(20.5%)被拒绝,12条(30.8%)未得到回应。拒绝的主要原因包括家属拒绝、对当前剂量反应良好以及因失眠加重需要增加剂量。
总体而言,药剂师的干预通过向医生提出简洁、基于证据的建议,可对减少老年人群不适当使用镇静/催眠药物产生有意义的影响。