Hasumi K, Kobayashi S, Hazato T, Hase K, Kaya K
Masui. 1989 Sep;38(9):1177-80.
Leucine enkephalin like substance (Leu-Enk) and enkephalin degrading enzyme activity (EDEA) in cerebrospinal fluid (CSF) of three patients suffering from pain were measured. As compared with control values before treatments, the values of Leu-Enk in CSF decreased, and those of EDEA increased in all the patients. After the treatment, two patients were fortunately cured of pain, and their two values returned to normal. But the other patient could not recover from severe pain, and their values remained abnormal. It is concluded that Leu-Enk and enkephalin degrading enzyme in CSF may play an important role in regulation of pain sensitivity.
对三名疼痛患者脑脊液中的亮氨酸脑啡肽样物质（Leu-Enk）和脑啡肽降解酶活性（EDEA）进行了测量。与治疗前的对照值相比，所有患者脑脊液中Leu-Enk的值均下降，而EDEA的值均升高。治疗后，两名患者幸运地治愈了疼痛，其两项指标恢复正常。但另一名患者的严重疼痛未能缓解，其指标仍异常。结论是，脑脊液中的Leu-Enk和脑啡肽降解酶可能在疼痛敏感性调节中起重要作用。
