Yao William C, Emerick Kevin S, Kraft Stefan, Holbrook Eric H
Allergy Rhinol (Providence). 2016 Jan 1;7(3):164-167. doi: 10.2500/ar.2016.7.0174.
The progression from a benign pigmented lesion on the skin to cutaneous melanoma is better understood, and it could be presumed that a similar progression occurs with mucosal lesions. However, to our knowledge, there has never been documentation of melanosis transforming into melanoma over time.
To describe a transformation of a mucosal melanosis into melanoma.
A 53-year-old man with diffuse melanosis of the nasal cavity underwent surgical resection.
Pathology revealed melanocytic hyperplasia without evidence of melanoma. The patient was serially examined, with excisions for new areas of melanosis. The pathology progressed to severely atypical melanocytic proliferation and melanoma in situ over a 4-year period.
Nasal melanosis may be a precancerous lesion and may transform into melanoma. All melanosis should be biopsied with close endoscopic observation. Lesions with dysplasia or atypia should be excised due to potential transformation to melanoma.
从皮肤上的良性色素沉着病变发展为皮肤黑色素瘤的过程已得到更好的理解，可以推测黏膜病变也会发生类似的进展。然而，据我们所知，从未有过黑色素沉着随时间转变为黑色素瘤的文献记载。
描述一例黏膜黑色素沉着转变为黑色素瘤的病例。
对一名患有鼻腔弥漫性黑色素沉着的53岁男性进行手术切除。
病理显示黑素细胞增生，但无黑色素瘤证据。对患者进行了连续检查，并对新出现的黑色素沉着区域进行切除。病理结果在4年时间里进展为严重非典型黑素细胞增殖和原位黑色素瘤。
鼻腔黑色素沉着可能是一种癌前病变，可能转变为黑色素瘤。所有黑色素沉着均应进行活检并密切内镜观察。因有转变为黑色素瘤的潜在风险，有发育异常或非典型性的病变应予以切除。
