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头孢特仑新戊酯在儿科领域的临床研究

[Clinical studies on cefteram pivoxil in the field of pediatrics].

作者信息

Shinozaki T, Nonaka C, Togasaki K

机构信息

Department of Pediatrics, Tokyo Kosei-Nenkin Hospital.

出版信息

Jpn J Antibiot. 1989 Aug;42(8):1837-44.

PMID:2810746
Abstract

Cefteram pivoxil (CFTM-PI) was administered to 37 patients with acute febrile upper or lower respiratory infections and 3 patients with urinary tract infections at 10 mg/kg/day divided into 3 portions. Good clinical effects were observed in all the cases. As for the bacteriological effect, the evaluable 24 strains (60.0%) were eradicated among 43 strains identified in 37 cases with the treatment with CFTM-PI. Only 2 strains were eradicated among 9 strains of Staphylococcus aureus. Among 3 patients with urinary tract infections with Escherichia coli, 2 strains were eradicated from urine after the administration of CFTM-PI. Four cases showed mild diarrhea among 40 cases. It was not clear whether the diarrhea was due to the administration of CFTM-PI.

摘要

头孢特仑新戊酯(CFTM-PI)以每日10mg/kg的剂量分3次给予37例急性发热性上呼吸道或下呼吸道感染患者及3例尿路感染患者。所有病例均观察到良好的临床效果。在细菌学效果方面,用CFTM-PI治疗的37例患者中鉴定出的43株菌株中有24株(60.0%)可评价菌株被根除。金黄色葡萄球菌的9株菌株中仅2株被根除。3例大肠杆菌引起的尿路感染患者中,给予CFTM-PI后有2株从尿液中被根除。40例中有4例出现轻度腹泻。尚不清楚腹泻是否由CFTM-PI给药所致。

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