School of Biochemistry and Cell Biology, University College Cork, Cork T12 YT57, Ireland; Department of Human Genetics, University of Utah, Salt Lake City, UT 84112-5330, USA.
School of Biochemistry and Cell Biology, University College Cork, Cork T12 YT57, Ireland.
Mol Cell. 2017 Jan 19;65(2):203-204. doi: 10.1016/j.molcel.2017.01.002.
In many bacteria, separate genes encode a copper binding chaperone and a copper efflux pump, but in some the chaperone encoding gene has been elusive. In this issue of Molecular Cell, Meydan et al. (2017) report that ribosomes translating the ORF that encodes the copper pump frequently frameshift and terminate to produce the copper chaperone.
在许多细菌中，单独的基因编码铜结合伴侣和铜外排泵，但在某些细菌中，伴侣编码基因一直难以捉摸。在本期《分子细胞》中，Meydan 等人（2017 年）报告称，核糖体翻译编码铜泵的 ORF 时经常发生移码和终止，从而产生铜伴侣。
