Tanabe A
Third Department of Internal Medicine, Kurume University School of Medicine, Japan.
Jpn Heart J. 1989 Jul;30(4):497-509. doi: 10.1536/ihj.30.497.
This study compared the hemodynamic effects of verapamil with other interventions that alter loading conditions in canines. The close correlation between peak filling velocity and systolic excursion indicated that peak filling velocity was dependent on systolic performance. However, verapamil caused a significantly greater increase in peak filling velocity than nitroprusside or volume loading despite a comparable increase in systolic excursion. Although both verapamil and volume loading induced increases in the peak filling velocity, the end-diastolic pressure and the peak pressure of the atrial v-wave, the pressure at the nadir of the atrial y-wave fell after verapamil but rose after volume loading. The rate of y-descent was also significantly greater after verapamil than after volume loading. These results indicate that, in addition to a reduction in afterload and an increase in preload, verapamil has a direct beneficial effect on ventricular filling.
本研究比较了维拉帕米与其他改变犬类负荷条件的干预措施的血流动力学效应。峰值充盈速度与收缩期偏移之间的密切相关性表明，峰值充盈速度取决于收缩期功能。然而，尽管收缩期偏移有类似增加，但维拉帕米引起的峰值充盈速度增加显著大于硝普钠或容量负荷。虽然维拉帕米和容量负荷均导致峰值充盈速度增加，但舒张末期压力和心房v波的峰值压力在维拉帕米作用后下降，而在容量负荷后上升。维拉帕米作用后的y波下降速率也显著大于容量负荷后。这些结果表明，除了降低后负荷和增加前负荷外，维拉帕米对心室充盈有直接的有益作用。
