Sekine T, Takagi M, Uemura Y, Mori Y, Wada H, Minami N, Deguchi K, Shirakawa S
Rinsho Ketsueki. 1989 Jul;30(7):1021-6.
A 51-year-old women in menopause was admitted because of intermittent purpura. She was diagnosed as having cyclic thrombocytopenia. One platelet cycle lasted for about 22 days with platelet count fluctuating from 1.0 X 10(4)/microliters to 31.0 X 10(4)/microliters. The platelet-associated immunoglobulin was correlated with the platelet cycle. The rheumatic factor, antinuclear antibody, antimicrosome antibody, anti-thyroglobulin antibody and platelet binding immunoglobulin were all positive but did not fluctuate during the cycle. The platelet life-span was shortened. The mean platelet volume fluctuated during each cycle. The lipid emulsion test was prolonged. Symptoms of Sjögren syndrome and purpura appeared at the same time. It was strongly suggested that purpura was caused by cyclical destruction of platelets by reticuloendothelial system.
一名51岁的绝经后女性因间歇性紫癜入院。她被诊断为周期性血小板减少症。一个血小板周期持续约22天，血小板计数在1.0×10⁴/微升至31.0×10⁴/微升之间波动。血小板相关免疫球蛋白与血小板周期相关。类风湿因子、抗核抗体、抗微粒体抗体、抗甲状腺球蛋白抗体及血小板结合免疫球蛋白均为阳性，但在周期中无波动。血小板寿命缩短。每个周期中平均血小板体积波动。脂乳试验延长。干燥综合征症状和紫癜同时出现。强烈提示紫癜是由网状内皮系统对血小板的周期性破坏所致。
