Liaveri Paraskevi G, Dikeos Dimitris, Ilias Ioannis, Lygkoni Eirini P, Boletis Ioannis N, Skalioti Chryssanthi, Paparrigopoulos Thomas
Dialysis Unit, "Protypo Nefrologiko Kentro Attikis", Athens, Greece.
Sleep Research Unit, First Department of Psychiatry, National and Kapodistrian University of Athens, Medical School, "Eginition" Hospital, Athens, Greece.
J Psychosom Res. 2017 Feb;93:96-101. doi: 10.1016/j.jpsychores.2016.12.013. Epub 2016 Dec 27.
Sleep disorders are very common in patients with chronic kidney disease and they may not always subside after kidney transplantation.
The aim of this cross-sectional study was to evaluate the self-reported quality of sleep, insomnia problems in particular, and examine the factors that disturb sleep of kidney transplant recipients (KTx: n=152) in comparison to age- and sex-matched patients on dialysis (HD: n=67) and participants with normal renal function (NOR: n=49), through the administration of the Athens Insomnia Scale (AIS) at least six months after transplantation. Clinical and laboratory data, as well as health-related quality of life, depression, anxiety, post-traumatic stress symptoms, and the presence of restless legs syndrome (RLS) and pruritus were investigated in relation to sleep problems.
The highest mean AIS score was observed in the transplant patients (KTx: 4.6±13.3 vs. HD: 3.8±8.1 vs. NOR: 2.4±10.2); both KTx and HD patients had a lower quality of sleep compared to participants with normal renal function. Multiple linear regression analysis showed that the determinants of the total AIS score were the frequency of post-traumatic stress symptoms, depression, RLS, diastolic blood pressure, and pain (all p<0.0001).
Although amelioration of renal function post-transplantation improves several aspects of quality of life, it does not seem to have a beneficial effect on self-reported sleep.
睡眠障碍在慢性肾脏病患者中非常常见，且在肾移植后可能并不总是会缓解。
这项横断面研究的目的是评估自我报告的睡眠质量，尤其是失眠问题，并通过在移植后至少六个月使用雅典失眠量表（AIS），来检查与年龄和性别匹配的透析患者（HD：n = 67）及肾功能正常的参与者（NOR：n = 49）相比，肾移植受者（KTx：n = 152）睡眠受干扰的因素。研究了临床和实验室数据，以及与睡眠问题相关的健康相关生活质量（HRQoL）、抑郁、焦虑、创伤后应激症状、不宁腿综合征（RLS）和瘙痒的情况。
移植患者的平均AIS得分最高（KTx：4.6±13.3，HD：3.8±8.1，NOR：2.4±10.2）；与肾功能正常的参与者相比，KTx和HD患者的睡眠质量均较低。多元线性回归分析表明，AIS总分的决定因素是创伤后应激症状的频率、抑郁、RLS、舒张压和疼痛（所有p<0.0001）。
尽管移植后肾功能的改善可提高生活质量的多个方面，但似乎对自我报告的睡眠没有有益影响。
