Kobayashi H, Ogawa T
Rinsho Ketsueki. 1989 Jul;30(7):1093-4.
We present a case of a 63-year-old man who was diagnosed CML at the onset of bladder transitional carcinoma. He had been treated with subcutaneous injection of natural interferon-alpha at the dose of 2 X 10(6) U on consecutive days. Four weeks later, he achieved remission and then received curative operation. Ph1 chromosome transiently decreased to 40%. For more than 16 months, he remained in remission. Since in CML Ph1 clone can be found in B cells and CML itself may result in hypogammaglobulinemia which may be basis of carcinogenesis, it was speculated that hypogammaglobulinemia found in this case related to carcinogenesis.
我们报告一例63岁男性患者，在膀胱移行癌发病时被诊断为慢性粒细胞白血病（CML）。他接受了连续皮下注射天然α干扰素治疗，剂量为每日2×10⁶单位。四周后，他达到缓解状态，随后接受了根治性手术。Ph1染色体暂时降至40%。在超过16个月的时间里，他一直处于缓解状态。由于在CML中，Ph1克隆可在B细胞中发现，且CML本身可能导致低丙种球蛋白血症，而这可能是致癌的基础，因此推测该病例中发现的低丙种球蛋白血症与致癌作用有关。
