Ahmed Shenaz, Jafri Hussain, Rashid Yasmin, Mason Gerald, Ehsan Yasmin, Ahmed Mushtaq
Leeds Institute of Health Sciences, School of Medicine, University of Leeds, Leeds, LS2 9NL, UK.
Genetech Laboratory, Lahore, Pakistan.
Prenat Diagn. 2017 Mar;37(3):289-295. doi: 10.1002/pd.5008. Epub 2017 Feb 10.
Stakeholders' views are essential for informing implementation strategies for non-invasive prenatal testing (NIPT). Little is known about such views in developing countries. We explored attitudes towards NIPT among obstetricians in Pakistan, a developing, Islamic country.
A 35-item questionnaire was distributed and collected at eight events (a national conference and seven workshops in five cities) for obstetric professionals on advances in fetal medicine.
Responses from 113 obstetrician show positive attitudes towards implementation of NIPT: 95% agreed prevention of genetic conditions was a necessity, and 97% agreed public hospitals should provide prenatal screening tests. However, participants also agreed the availability of NIPT would increase social pressure on women to have prenatal screening tests and to terminate an affected pregnancy (53% and 63%, respectively). Most participants would not offer NIPT for sex determination (55%), although 31% would. The most valued aspects of NIPT were its safety, followed by its utility and then accuracy.
Participants generally supported the implementation of NIPT but raised concerns about social implications. Therefore, national policy is needed to regulate the implementation of NIPT, and pretest information and post-test genetic counselling are needed to mitigate social pressure and support parents to make informed decisions. © 2017 John Wiley & Sons, Ltd.
利益相关者的观点对于为无创产前检测(NIPT)的实施策略提供信息至关重要。在发展中国家,对此类观点了解甚少。我们在巴基斯坦这个发展中的伊斯兰国家,探讨了产科医生对NIPT的态度。
在八个针对产科专业人员的胎儿医学进展活动(一个全国性会议和在五个城市举办的七个研讨会)上分发并收集了一份包含35个条目的问卷。
113位产科医生的回复显示出对实施NIPT的积极态度:95%的人认为预防遗传疾病很有必要,97%的人认为公立医院应提供产前筛查检测。然而,参与者也认同NIPT的可获得性会增加女性接受产前筛查检测以及终止受影响妊娠的社会压力(分别为53%和63%)。大多数参与者不会提供用于性别鉴定的NIPT(55%),尽管31%的人会。NIPT最受重视的方面是其安全性,其次是实用性,然后是准确性。
参与者普遍支持实施NIPT,但对其社会影响表示担忧。因此,需要国家政策来规范NIPT的实施,并且需要进行检测前信息告知和检测后遗传咨询,以减轻社会压力并支持父母做出明智的决定。© 2017约翰·威利父子有限公司