Bagheri Vahid
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Cytokine. 2017 Apr;92:80-82. doi: 10.1016/j.cyto.2017.01.009. Epub 2017 Jan 18.
In humans, S100A12 (also named Calgranulin C and EN-RAGE) is mainly expressed and secreted by neutrophil granulocytes. Extracellular S100A12 is involved in innate immune responses against microorganisms and parasites. S100A12 is a ligand for the receptor for advanced glycation end products (RAGE), which is a cell surface receptor on macrophages, endothelium, and lymphocytes. In a recent study, Realegeno et al. showed that S100A12 exerts antimicrobial activity against Mycobacterium leprae in infected human macrophages. Recently, some interesting data on the antimicrobial activity of S100A12 have been reported. Proinflammatory role of S100A12 is supported by another newly found receptor, Toll-like receptor 4 (TLR4). These observations emphasize the importance of S100A12 for the development of potential therapeutic approaches to increase protective immunity or reduce immunopathogenesis.
在人类中，S100A12（也称为钙粒蛋白C和EN-RAGE）主要由中性粒细胞表达和分泌。细胞外的S100A12参与针对微生物和寄生虫的固有免疫反应。S100A12是晚期糖基化终产物受体（RAGE）的配体，RAGE是巨噬细胞、内皮细胞和淋巴细胞表面的一种细胞受体。在最近的一项研究中，雷亚莱根诺等人表明，S100A12在受感染的人类巨噬细胞中对麻风分枝杆菌具有抗菌活性。最近，已经报道了一些关于S100A12抗菌活性的有趣数据。另一种新发现的受体——Toll样受体4（TLR4）支持S100A12的促炎作用。这些观察结果强调了S100A12对于开发增强保护性免疫或减少免疫发病机制的潜在治疗方法的重要性。
