通过集成式PET/MRI利用联合[F]氟胆碱PET和氢磁共振波谱对前列腺癌进行基于胆碱的成像。
Choline-based imaging of prostate cancer with combined [F] fluorocholine PET and H MR spectroscopy by means of integrated PET/MRI.
作者信息
Wetter Axel, Grüneisen Johannes, Fliessbach Klaus, Lütje Susanne, Schaarschmidt Benedikt, Umutlu Lale
机构信息
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstraße 55, 45122 Essen, Germany.
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstraße 55, 45122 Essen, Germany.
出版信息
Clin Imaging. 2017 Mar-Apr;42:198-202. doi: 10.1016/j.clinimag.2016.12.008. Epub 2017 Jan 7.
PURPOSE
To evaluate integrated PET/MRI/H MR spectroscopy in patients with prostate cancer.
SUBJECTS AND METHODS
Data analysis comprised calculations of correlations of standardized uptake values (SUVs) and ratios of (choline+creatine)/citrate as well as of single metabolite values and a logistic regression analysis of PET data and MR spectroscopy data in 22 patients.
RESULTS
SUVmean and integral values of choline correlated significantly in tumors. Logistic regression analysis demonstrated diagnostic superiority of PET over spectroscopy.
CONCLUSION
Simultaneous acquisition of PET and MR spectroscopy with integrated PET/MRI is feasible. Choline compounds and choline metabolism show a positive significant correlation.
目的
评估正电子发射断层显像/磁共振成像/氢磁共振波谱（PET/MRI/H MRS）在前列腺癌患者中的应用。
对象与方法
对22例患者的数据分析包括标准化摄取值（SUV）与（胆碱+肌酸）/枸橼酸盐比值的相关性计算、单一代谢物值的计算以及PET数据和磁共振波谱数据的逻辑回归分析。
结果
肿瘤内SUV均值与胆碱积分值显著相关。逻辑回归分析显示PET在诊断方面优于波谱。
结论
采用一体化PET/MRI同时采集PET和磁共振波谱是可行的。胆碱化合物与胆碱代谢呈显著正相关。
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