Makarychev V A, Nasledkov V N, Ivanitskaia E V
Kardiologiia. 1989 Jul;29(7):81-5.
Experimental rabbits were subjected to a ventricular rate-decreasing paired pacing over an hour. Ventricular rates showed a 1.4-1.9-fold decrease, whereas left ventricular pressure evolution became higher, the periods of ejection and myocardial isovolumetric relation, longer, aortic diastolic pressure, lower than the baseline values. The induction thresholds of ventricular fibrillation were decreased from 16.5 +/- 1.6 mA to 7.2 +/- 3.1 mA (p less than less than 0.001). The examination of left ventricular myocardial ultrastructure indicated that the paired stimulation regimen resulted in focal contractural changes in myocardiocytes to form overcontraction zones.
对实验兔进行一小时的心室率降低配对起搏。心室率下降了1.4至1.9倍，而左心室压力变化升高，射血期和心肌等容关系期延长，主动脉舒张压低于基线值。心室颤动的诱发阈值从16.5±1.6毫安降至7.2±3.1毫安（p远小于0.001）。左心室心肌超微结构检查表明，配对刺激方案导致心肌细胞出现局灶性收缩变化，形成过度收缩区。
