外周血CD34细胞作为孕早期流产的一种新型非侵入性早期标志物：病例对照分析结果
Peripheral blood CD34 cells as a novel and noninvasive early marker of first trimester miscarriage: results from a case-control analysis.
作者信息
Giordano Domenico, Loddo Saverio, Laganà Antonio Simone, Coppolino Giuseppe, Zoccali Giuseppe, Di Benedetto Antonino, Santamaria Angelo, Buemi Michele, D'Anna Rosario
机构信息
a Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi" , University of Messina , Messina , Italy.
b Department of Experimental Medicine , University of Messina , Messina , Italy.
出版信息
J Matern Fetal Neonatal Med. 2018 Jan;31(2):258-260. doi: 10.1080/14767058.2016.1277703. Epub 2017 Jan 23.
PURPOSE
To evaluate the levels of peripheral blood CD34cells in women who subsequently had a spontaneous miscarriage (SM).
MATERIALS AND METHODS
We enrolled 11 women who had SM, matching them for age, BMI and gestational age with 33 healthy pregnancies (controls). From a blood sample at 9th-11th weeks of pregnancy, we evaluated PAPP-A, free β-hCG, T (suppressor and helper), NK, B, CD34cells.
RESULTS
In peripheral blood of women who had SM, PAPP-A and CD34cells were significantly lower (p < 0.001) compared to control group.
CONCLUSIONS
CD34cell low level in peripheral blood is associated with increased risk of SM.
目的
评估随后发生自然流产（SM）的女性外周血CD34细胞水平。
材料与方法
我们招募了11例发生自然流产的女性，将她们在年龄、体重指数和孕周方面与33例正常妊娠（对照组）进行匹配。在妊娠第9至11周采集血样，评估妊娠相关血浆蛋白-A（PAPP-A）、游离β-人绒毛膜促性腺激素（β-hCG）、T细胞（抑制性和辅助性）、自然杀伤细胞（NK）、B细胞、CD34细胞。
结果
与对照组相比，发生自然流产的女性外周血中PAPP-A和CD34细胞显著降低（p < 0.001）。
结论
外周血CD34细胞水平低与自然流产风险增加有关。
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