中国人群中杀伤细胞免疫球蛋白样受体与急性髓系白血病的关联

Associations of killer cell immunoglobulin-like receptors with acute myeloid leukemia in Chinese populations.

作者信息

Tao Sudan, He Yanmin, Dong Lina, He Junjun, Chen Nanying, Wang Wei, Han Zhedong, Zhang Wei, He Ji, Zhu Faming

机构信息

Blood Center of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China; Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, Zhejiang, People's Republic of China; Zhejiang Provincial Key Laboratory of Blood Safety Research, Hangzhou, Zhejiang, People's Republic of China.

出版信息

Hum Immunol. 2017 Mar;78(3):269-273. doi: 10.1016/j.humimm.2017.01.005. Epub 2017 Jan 20.

DOI:10.1016/j.humimm.2017.01.005

PMID:28111167

Abstract

Many studies have investigated the relationship between KIR, HLA and acute myeloid leukemia (AML), but the results were different in different laboratories, and the data in Chinese population were limited. In this study, the distribution of KIR gene, KIR genotypes, HLA-C groups, HLA-Bw4, and KIR-HLA interaction from 273 healthy participants and 253 AML patients (M0-M6) in southern Chinese Han were determined to investigate the relationships among KIR, HLA and AML. The results showed that the frequencies of 2DS4del in M5 patients were significantly higher than those of the controls (65.0% vs 46.5%, P=0.0104, OR=2.135, P<ɑ'). The frequency of KIR genotype BX13 in the healthy controls was significantly higher than that in AML patients (3.7% vs 0%, P=0.0019, OR=20.2, P<ɑ'). No other significant differences in the frequencies of KIR, HLA and KIR-HLA interaction were identified between AML patients and controls. Our study suggests that 2DS4del may conduct a susceptibility to AML, and genotype BX13 might conduct a protective effect on AML.

摘要

许多研究调查了杀伤细胞免疫球蛋白样受体（KIR）、人类白细胞抗原（HLA）与急性髓系白血病（AML）之间的关系，但不同实验室的结果各异，且中国人群的数据有限。在本研究中，测定了中国南方汉族273名健康参与者和253例AML患者（M0 - M6）的KIR基因分布、KIR基因型、HLA - C组、HLA - Bw4以及KIR - HLA相互作用，以探讨KIR、HLA与AML之间的关系。结果显示，M5患者中2DS4del的频率显著高于对照组（65.0%对46.5%，P = 0.0104，OR = 2.135，P <ɑ'）。健康对照组中KIR基因型BX13的频率显著高于AML患者（3.7%对0%，P = 0.0019，OR = 20.2，P <ɑ'）。AML患者与对照组之间在KIR、HLA及KIR - HLA相互作用频率方面未发现其他显著差异。我们的研究表明，2DS4del可能对AML具有易感性，而基因型BX13可能对AML具有保护作用。