Burke Andrew R, McCormick Cheryl M, Pellis Sergio M, Lukkes Jodi L
Department of Psychiatry, Indiana University School of Medicine, 320 West 15th Street, Indianapolis, IN, 46202, USA.
Centre for Neuroscience, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario, L2S 3A1, Canada.
Neurosci Biobehav Rev. 2017 May;76(Pt B):280-300. doi: 10.1016/j.neubiorev.2017.01.018. Epub 2017 Jan 20.
Negative social experiences during adolescence are central features for several stress-related mental illnesses. Social play fighting behavior in rats peaks during early adolescence and is essential for the final maturation of brain and behavior. Manipulation of the rat adolescent social experience alters many neurobehavioral measurements implicated in anxiety, depression, and substance abuse. In this review, we will highlight the importance of social play and the use of three separate social stress models (isolation-rearing, social defeat, and social instability stress) to disrupt the acquisition of this adaptive behavior. Social stress during adolescence leads to the development of anxiety and depressive behavior as well as escalated drug use in adulthood. Furthermore, sex- and age-dependent effects on the hormonal stress response following adolescent social stress are also observed. Finally, manipulation of the social experience during adolescence alters stress-related neural circuits and monoaminergic systems. Overall, positive social experiences among age-matched conspecifics during rat adolescence are critical for healthy neurobehavioral maturation.
青春期的负面社会经历是几种与压力相关的精神疾病的核心特征。大鼠的社会玩耍打斗行为在青春期早期达到顶峰，对大脑和行为的最终成熟至关重要。对大鼠青春期社会经历的操控会改变许多与焦虑、抑郁和药物滥用相关的神经行为指标。在这篇综述中，我们将强调社会玩耍的重要性，以及使用三种不同的社会应激模型（隔离饲养、社会挫败和社会不稳定应激）来干扰这种适应性行为的习得。青春期的社会应激会导致焦虑和抑郁行为的发展，以及成年后药物使用的增加。此外，还观察到青春期社会应激后激素应激反应存在性别和年龄依赖性效应。最后，对青春期社会经历的操控会改变与应激相关的神经回路和单胺能系统。总体而言，大鼠青春期与年龄匹配的同种个体之间的积极社会经历对健康的神经行为成熟至关重要。
