与阿尔茨海默病淀粉样斑块结合的 N-杂环卡宾配体的铼（I）配合物。
Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease.
作者信息
Chan Chung Ying, Noor Asif, McLean Catriona A, Donnelly Paul S, Barnard Peter J
机构信息
Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia.
School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.
出版信息
Chem Commun (Camb). 2017 Feb 16;53(15):2311-2314. doi: 10.1039/c6cc10066j.
A series of [Re(i)L(CO)] complexes (where L is a bifunctional bis(NHC)-amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyloid plaques in human frontal cortex brain tissue from subjects with Alzheimer's disease.
已经合成了一系列[Re(i)L(CO)]配合物（其中L是双功能双（NHC）-胺配体），它们是用于阿尔茨海默病的潜在锝-99m诊断成像剂的类似物。其中一种配合物与来自阿尔茨海默病患者的人类额叶皮质脑组织中的淀粉样斑块结合。
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