School of Chemistry, F11, The University of Sydney, NSW 2006, Australia.
Australian Nuclear Science and Technology Organisation, Locked Bag 2001, Kirrawee DC NSW 2232, Australia.
Soft Matter. 2017 Feb 15;13(7):1364-1370. doi: 10.1039/c6sm02652d.
The formation of bilayer-based lyotropic liquid crystals and vesicle dispersions by phospholipids in a range of protic ionic liquids has been investigated by polarizing optical microscopy using isothermal penetration scans, differential scanning calorimetry, and small angle X-ray and neutron scattering. The stability and structure of both lamellar phases and vesicle dispersions is found to depend primarily on the underlying amphiphilic nanostructure of the ionic liquid itself. This finding has significant implications for the use of ionic liquids in soft and biological materials and for biopreservation, and demonstrates how vesicle structure and properties can be controlled through selection of cation and anion. For a given ionic liquid, systematic trends in bilayer thickness, chain-melting temperature and enthalpy increase with phospholipid acyl chain length, paralleling behaviour in aqueous systems.
通过等温渗透扫描、差示扫描量热法、小角 X 射线和中子散射，用偏光显微镜研究了一系列质子离子液体中磷脂形成双层各向同性液晶和囊泡分散体的过程。发现层状相和囊泡分散体的稳定性和结构主要取决于离子液体本身的基础两亲性纳米结构。这一发现对于离子液体在软质和生物材料以及生物保存中的应用具有重要意义，并展示了如何通过选择阳离子和阴离子来控制囊泡结构和性质。对于给定的离子液体，双层厚度、链熔化温度和焓的系统趋势随磷脂酰链长度增加而增加，与水相系统的行为平行。
