Choi Jin Gyu, Kim Namkwon, Huh Eugene, Lee Hwan, Oh Myeong Hwan, Park Jong Dae, Pyo Mi Kyung, Oh Myung Sook
Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea.
Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea.
Phytother Res. 2017 Mar;31(3):497-506. doi: 10.1002/ptr.5776. Epub 2017 Jan 23.
Amyloid-beta oligomer (AβO) is a soluble oligomer form of the Aβ peptide and the most potent amyloid-beta form that induces neuronal damage in Alzheimer's disease. We investigated the effect of dried white ginseng extract (WGE) on neuronal cell damage and memory impairment in intrahippocampal AβO (10 μM)-injected mice. Mice were treated with WGE (100 and 500 mg/kg/day, p.o.) for 12 days after surgery. WGE improved memory impairment by inhibiting hippocampal cell death caused by AβO. In addition, AβO-injected mice treated with WGE showed restoration of reduced synaptophysin and choline acetyltransferase intensity and lower levels of ionized calcium-binding adaptor molecule 1 in the hippocampus compared with those of vehicle-treated controls. These results suggest that WGE reverses memory impairment in Alzheimer's disease by attenuating neuronal damage and neuroinflammation in the AβO-injected mouse hippocampus. Copyright © 2017 John Wiley & Sons, Ltd.
β淀粉样蛋白寡聚体（AβO）是Aβ肽的一种可溶性寡聚体形式，也是在阿尔茨海默病中诱导神经元损伤的最具毒性的β淀粉样蛋白形式。我们研究了干白参提取物（WGE）对海马内注射AβO（10 μM）的小鼠神经元细胞损伤和记忆障碍的影响。小鼠在手术后接受WGE（100和500 mg/kg/天，口服）治疗12天。WGE通过抑制AβO引起的海马细胞死亡改善了记忆障碍。此外，与溶剂处理的对照组相比，接受WGE治疗的AβO注射小鼠海马中的突触素和胆碱乙酰转移酶强度降低得到恢复，且离子钙结合衔接分子1水平降低。这些结果表明，WGE通过减轻AβO注射小鼠海马中的神经元损伤和神经炎症来逆转阿尔茨海默病中的记忆障碍。版权所有© 2017约翰威立父子有限公司。
