Turton J A, Hawkey C M, Hart M G, Gwynne J, Hicks R M
Department of Cell Pathology, School of Pathology, Middlesex Hospital Medical School, London, UK.
Lab Anim. 1989 Oct;23(4):295-301. doi: 10.1258/002367789780746006.
As little comprehensive baseline data are available on age-related haematological changes in genetically-defined rat strains, the haematology of female F344 rats is described in animals sampled at 2, 4, 8, 20, 66 and 121 weeks of age. Values for Hb, RBC and PCV increased from 2 weeks of age to reach adult levels at 8 weeks, whereas MCV, MCH and reticulocyte counts were high initially but decreased to reach the adult range at 8 weeks. Between 66 and 121 weeks, reticulocyte counts were significantly increased and values for MCHC significantly decreased. Lymphocytes were the predominant white cell type in each age group. The absolute numbers of neutrophils and lymphocytes showed slight variations between 2 and 66 weeks and both cell types increased significantly between 66 and 121 weeks. Platelet counts showed no overall age-related trends. Fibrinogen values increased from 2 weeks of age to reach the adult level at 8 weeks. One animal of the 14 sampled at 121 weeks showed changes in the blood, liver and spleen consistent with a diagnosis of lymphoid leukaemia.
由于关于基因定义大鼠品系中与年龄相关的血液学变化的全面基线数据很少，因此描述了在2、4、8、20、66和121周龄时采样的雌性F344大鼠的血液学情况。血红蛋白（Hb）、红细胞（RBC）和红细胞压积（PCV）的值从2周龄开始升高，在8周龄时达到成年水平，而平均红细胞体积（MCV）、平均红细胞血红蛋白含量（MCH）和网织红细胞计数最初较高，但在8周龄时降至成年范围。在66至121周之间，网织红细胞计数显著增加，平均红细胞血红蛋白浓度（MCHC）值显著降低。淋巴细胞是每个年龄组中主要的白细胞类型。中性粒细胞和淋巴细胞的绝对数量在2至66周之间略有变化，两种细胞类型在66至121周之间均显著增加。血小板计数未显示出与年龄相关的总体趋势。纤维蛋白原值从2周龄开始升高，在8周龄时达到成年水平。在121周龄采样的14只动物中有1只动物的血液、肝脏和脾脏出现了与淋巴样白血病诊断一致的变化。
