C57BL/10J小鼠的骨肿瘤

Tumours of the bone in C57BL/10J mice.

作者信息

Wadsworth P F

机构信息

Imperial Chemical Industries, PLC, ICI Pharmaceuticals, Macclesfield, Cheshire, UK.

出版信息

Lab Anim. 1989 Oct;23(4):324-7. doi: 10.1258/002367789780745971.

DOI:10.1258/002367789780745971

PMID:2811271

Abstract

Tumours of the bone were found in 17 (12 females and 5 males) of 6768 (0.25%) C57BL/10J mice (3384 males and 3384 females) pooled from 14 oncogenic studies carried out from 1973 to 1987. Tumours of bone were found predominantly in female mice and were age related. The tumours were classified histologically as osteosarcoma (5 osteoblastic, 6 mixed type and 1 fibroblastic), chondroma (2), chondromyxoid fibroma (1), chondrosarcoma (1) and periosteal fibroma (1).

摘要

在1973年至1987年开展的14项致癌性研究中汇集的6768只（3384只雄性和3384只雌性）C57BL/10J小鼠中，发现17只（12只雌性和5只雄性）出现骨肿瘤（占0.25%）。骨肿瘤主要在雌性小鼠中发现，且与年龄相关。这些肿瘤经组织学分类为骨肉瘤（5例成骨细胞型、6例混合型和1例纤维母细胞型）、软骨瘤（2例）、软骨黏液样纤维瘤（1例）、软骨肉瘤（1例）和骨膜纤维瘤（1例）。