Özkurt Zübeyde Nur, Sucak Gülsan Türköz, Akı Şahika Zeynep, Yağcı Münci, Haznedar Rauf
a Department of Hematology , Gazi University School of Medicine , Ankara , Turkey.
Cancer Invest. 2017 Mar 16;35(3):195-201. doi: 10.1080/07357907.2016.1270958. Epub 2017 Jan 23.
We hypothesized the levels of free light chains obtained before and after autologous stem cell transplantation can be useful in predicting transplantation outcome. We analyzed 70 multiple myeloma patients. Abnormal free light chain ratios before stem cell transplantation were found to be associated early progression, although without any impact on overall survival. At day +30, the normalization of levels of involved free light chain related with early progression. According to these results almost one-third reduction of free light chain levels can predict favorable prognosis after autologous stem cell transplantation.
我们推测，自体干细胞移植前后获得的游离轻链水平可用于预测移植结果。我们分析了70例多发性骨髓瘤患者。发现干细胞移植前游离轻链比例异常与早期进展相关，尽管对总生存期没有任何影响。在第30天，受累游离轻链水平的正常化与早期进展相关。根据这些结果，游离轻链水平降低近三分之一可预测自体干细胞移植后的良好预后。
