Madrenas J, Vallés M, Ruiz Marcellan M C, Fort J, García Bragado F, Pelegrí A
Med Clin (Barc). 1989 Sep 16;93(7):262-4.
A 49-year-old male with essential mixed cryoglobulinemia IgM kappa-IgG of 4-years duration was treated with corticosteroids and immunosuppressive drugs during the repeated episodes. Finally, he developed a new episode with severe renal involvement and pulmonary hemorrhage without other associated etiological factors. The optical and immunofluorescent histological findings in lung and kidney are described. This is the second case of pulmonary hemorrhage and cryoglobulinemia associated with essential mixed cryoglobulinemia reported in the literature. A relation between essential mixed cryoglobulinemia and glomerulonephritis and pulmonary hemorrhage is suggested.
一名49岁男性，患有持续4年的原发性混合性冷球蛋白血症IgM κ-IgG，在反复发病期间接受了皮质类固醇和免疫抑制药物治疗。最后，他出现了一次新的发作，伴有严重的肾脏受累和肺出血，且无其他相关病因。描述了肺和肾的光学及免疫荧光组织学检查结果。这是文献中报道的第二例与原发性混合性冷球蛋白血症相关的肺出血和冷球蛋白血症病例。提示原发性混合性冷球蛋白血症与肾小球肾炎和肺出血之间存在关联。
