Askgaard Gro, Pottegård Anton, Fink-Jensen Anders
Ugeskr Laeger. 2017 Jan 16;179(3).
In this review, we summarize the evidence for benzodiazepines and barbiturates as alcohol withdrawal treatment and outline a treatment guideline. A number of randomized controlled trials (RCTs) indicate that benzodiazepine treatment decreases alcohol withdrawal seizures and is safe. For barbiturates, only a few RCTs have been undertaken, and barbiturates were not found to be superior to benzodiazepines. Consequently, we suggest that benzodiazepines should still be first-line treatment for alcohol withdrawal.
在本综述中，我们总结了苯二氮䓬类药物和巴比妥类药物用于酒精戒断治疗的证据，并概述了治疗指南。多项随机对照试验（RCT）表明，苯二氮䓬类药物治疗可降低酒精戒断性癫痫发作且安全。对于巴比妥类药物，仅进行了少数RCT，未发现巴比妥类药物优于苯二氮䓬类药物。因此，我们建议苯二氮䓬类药物仍应作为酒精戒断的一线治疗药物。
