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[急性和慢性实验中回肠和空肠储袋的电刺激]

[Electrostimulation of ileum and jejunum reservoirs in an acute and chronic experiment].

作者信息

Moritz A, Grundfest-Broniatowski S, Ilyes L, Kasick J, Jacobs G, Nose Y

机构信息

II. Chirurgische Universitätsklinik Wien.

出版信息

Langenbecks Arch Chir. 1989;374(5):267-71. doi: 10.1007/BF01261468.

Abstract

Voluntary control of the motility of intestinal reservoirs may be used to improve evacuation and continence. In 4 dogs a U-shaped jejunum pouch and in another 4 an ileum pouch was constructed and instrumented with stimulating and EMG electrodes and pressure lines. In the acute experiments jejunum pouch stimulation with 200 microseconds 1.67 kHz 30 mA increased the intrapouch pressure by 38 +/- 4 mm Hg (n = 6) and 500 microseconds 910 Hz 25 mA by 60 +/- 5 mm Hg (n = 3). The pressure increase in the awake animals was consistently lower (200 microseconds 4 +/- 6 mm Hg, n = 9; 500 microseconds 25 +/- 17, n = 11). The ileum pouch responded with a 37 +/- 10 mm Hg pressure increase (n = 9) to 50 ms 6 Hz 20 mA pulse trains. Ileum pouches could not be stimulated in the awake animal due to contraction of the abdominal wall. Electrostimulation may be used to contract and evacuate intestinal reservoirs but additional drug therapy or autonomic nerve stimulation will be necessary to lower the thresholds especially for ileum stimulation in the awake animal.

摘要

对肠道贮袋运动进行自主控制可用于改善排空和控便能力。在4只犬中构建了U形空肠袋,在另外4只犬中构建了回肠袋,并安装了刺激电极、肌电图电极和压力监测线。在急性实验中,用200微秒、1.67千赫、30毫安的电流刺激空肠袋,袋内压力升高38±4毫米汞柱(n = 6);用500微秒、910赫、25毫安的电流刺激时,压力升高60±5毫米汞柱(n = 3)。清醒动物中的压力升高始终较低(200微秒时为4±6毫米汞柱,n = 9;500微秒时为25±17毫米汞柱,n = 11)。回肠袋对50毫秒、6赫、20毫安的脉冲串刺激反应为压力升高37±10毫米汞柱(n = 9)。由于腹壁收缩,清醒动物中的回肠袋无法被刺激。电刺激可用于收缩和排空肠道贮袋,但可能需要额外的药物治疗或自主神经刺激来降低阈值,尤其是在清醒动物中刺激回肠时。

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