豚鼠盲肠带的神经介导兴奋

Nerve-mediated excitation of the taenia of the guinea-pig caecum.

Campbell G

J Physiol. 1966 Jul;185(1):148-59. doi: 10.1113/jphysiol.1966.sp007977.

Abstract

A study was made of the responses of the isolated taenia of the guinea-pig caecum to stimulation of the intramural nerves.2. Four types of response are described, made up of a contraction and/or a relaxation occurring during stimulation and an after-contraction occurring when stimulation is stopped.3. A delayed relaxation which sometimes occurred at the end of stimulation is also described.4. Atropine usually abolished the contractions occurring during stimulation. After-contractions either appeared or were increased in amplitude in the presence of atropine, and delayed relaxations were abolished.5. The anti-cholinesterase drug neostigmine could convert the response during stimulation from a relaxation to a contraction. After-contractions were often abolished by neostigmine and delayed relaxations appeared.6. It is concluded that the contractions which occurred during stimulation were mediated by cholinergic nerves. The after-contraction appears to be a rebound phenomenon, following the hyperpolarization of the muscle caused by stimulation of the inhibitory nerves. It is suggested that the delayed relaxation is caused by the effects of persisting inhibitory transmitter substance on cells which do not undergo rebound excitation.

摘要

对豚鼠盲肠孤立带对壁内神经刺激的反应进行了研究。
描述了四种反应类型，包括刺激期间发生的收缩和/或舒张，以及刺激停止时发生的后收缩。
还描述了有时在刺激结束时出现的延迟舒张。
阿托品通常可消除刺激期间发生的收缩。在阿托品存在的情况下，后收缩要么出现，要么幅度增加，且延迟舒张被消除。
抗胆碱酯酶药物新斯的明可将刺激期间的反应从舒张转变为收缩。新斯的明常可消除后收缩，并出现延迟舒张。
得出的结论是，刺激期间发生的收缩由胆碱能神经介导。后收缩似乎是一种反弹现象，是由抑制性神经刺激导致肌肉超极化后引起的。有人提出，延迟舒张是由于持续的抑制性递质物质对未经历反弹兴奋的细胞产生作用所致。