Wang Ping, Wang June, Yu Mingxia, Li Zhiqiang
Department of Clinical Laboratory and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Department of Clinical Laboratory and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China.
Dis Markers. 2016;2016:4580323. doi: 10.1155/2016/4580323. Epub 2016 Dec 27.
. To investigate the potential association of tumor necrosis factor- T-857C polymorphism with susceptibility to the five common malignant tumors. . A comprehensive search of PubMed/Medline, Embase, and Web of Science databases was performed up to November 2015. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. Subgroup analysis, heterogeneity analyses, and publication bias were also texted in the meta-analysis. . A total of twenty-two publications involving 5215 cases and 6755 controls were recruited. Overall, the meta-analysis revealed an increased risk between the TNF- T-857C polymorphism and gastric cancer susceptibility in T versus C model, heterozygote genetic model, and dominant genetic model. An increased risk between the TNF- T-857C polymorphism and hepatocellular cancer susceptibility in homozygote genetic model and recessive genetic model was also found. No significant association was found between the TNF- T-857C polymorphism and colorectal cancer, cervical cancer, and prostate cancer. . Our meta-analyses suggest that TNF- T-857C polymorphism may be associated with increased risk of gastric cancer and hepatocellular cancer development. Therefore, the TNF- T-857C polymorphism could be considered as one possible risk factor of gastric cancer and hepatocellular cancer according to our study.
研究肿瘤坏死因子 -T-857C 多态性与五种常见恶性肿瘤易感性之间的潜在关联。
截至2015年11月，对PubMed/Medline、Embase和Web of Science数据库进行了全面检索。计算合并比值比（OR）和95%置信区间（95%CI）以评估关联强度。在荟萃分析中还进行了亚组分析、异质性分析和发表偏倚检验。
共纳入22篇涉及5215例病例和6755例对照的文献。总体而言，荟萃分析显示，在T对C模型、杂合子遗传模型和显性遗传模型中，肿瘤坏死因子 -T-857C 多态性与胃癌易感性之间存在风险增加。在纯合子遗传模型和隐性遗传模型中，也发现肿瘤坏死因子 -T-857C 多态性与肝细胞癌易感性之间存在风险增加。未发现肿瘤坏死因子 -T-857C 多态性与结直肠癌、宫颈癌和前列腺癌之间存在显著关联。
我们的荟萃分析表明，肿瘤坏死因子 -T-857C 多态性可能与胃癌和肝细胞癌发生风险增加有关。因此，根据我们的研究，肿瘤坏死因子 -T-857C 多态性可被视为胃癌和肝细胞癌的一个可能风险因素。
