Fidler L M, Aleksander S K, Mit'kov V B, Pugachev K K, Lukin Iu V, Avdeev G I
Med Radiol (Mosk). 1989 Oct;34(10):53-7.
131I-antibodies to human beta 1 colonic antigen was administered i.v. to nude mice with transplanted human colon carcinoma. Injections were followed by mouse whole-body investigation with the help of gamma-camera and scanner. The distribution of radioactivity in murine tissues was investigated with a gamma-counter. Sharp images of tumor were obtained with the help of the gamma-camera and scanner. The results of visualization were in accord with radioimmunometric data. A conclusion was made of effective visualization of human colon carcinoma transplanted to nude mice using iodinated antibodies to specific beta 1 MA epithelial colonic antigen.
将抗人β1结肠抗原的131I抗体静脉注射给移植了人结肠癌的裸鼠。注射后，借助γ相机和扫描仪对小鼠进行全身检查。用γ计数器研究放射性在鼠组织中的分布。借助γ相机和扫描仪获得了肿瘤的清晰图像。可视化结果与放射免疫测定数据一致。得出结论，使用针对特定β1 MA结肠上皮抗原的碘化抗体可有效可视化移植到裸鼠体内的人结肠癌。
