Gao Meng-Shan, Liu Shuai, Wang Ai-Wu
Stomatological Hospital of Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration. Jinan 250012, China E-mail:
Shanghai Kou Qiang Yi Xue. 2016 Oct;25(5):579-582.
To prepare Koukuining granules and observe its efficiency in the treatment of recurrent aphthas ulce (RAU).
In accordance with the theories of traditional Chinese medicine, the prescriptions of Koukuining granules were composed of rhizoma coptidis, radix scutellariae and other Chinese herbs, and the preparation procedure was conducted by means of wet granulation technology. One hundred patients with RAU were randomly divided into experimental group and control group equally. Patients in the experimental group took particles orally after a meal, 3 times a day, 1 bag each time, for successive 10 days as one treatment course. The treatment was repeated after 3 days of interval. Patients in the control group took vitamin C, compound vitamin B2, orally for 2 courses. The treatment effect was evaluated. Data analysis was performed using SPSS 11.5 software package.
The preparation process was controllable and the quality of the products was stable. The overall effective rate of the experimental group was 88.4% and there was a significant difference compared with the control group.
The preparation of Koukuining granules was feasible with stable quality of final products. Treatment of RAU with the granules was effective and worthy of clinical application.
制备口溃宁颗粒并观察其治疗复发性阿弗他溃疡（RAU）的疗效。
根据中医理论，口溃宁颗粒处方由黄连、黄芩等中药组成，采用湿法制粒技术进行制备。将100例RAU患者随机分为实验组和对照组，每组各50例。实验组患者饭后口服颗粒剂，每日3次，每次1袋，连续服用10天为1个疗程，间隔3天后重复治疗。对照组患者口服维生素C、复合维生素B2，治疗2个疗程。评价治疗效果。采用SPSS 11.5软件包进行数据分析。
制备工艺可控，产品质量稳定。实验组总有效率为88.4%，与对照组相比有显著差异。
口溃宁颗粒制备可行，成品质量稳定。口溃宁颗粒治疗RAU疗效显著，值得临床应用。
