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开窗术对不同风险水平的心外Fontan手术患者术后早期结局的影响。

Effect of Fenestration on Early Postoperative Outcome in Extracardiac Fontan Patients with Different Risk Levels.

作者信息

Fan Fan, Liu Zhimin, Li Shoujun, Yi Tong, Yan Jun, Yan Fuxia, Wang Xu, Wang Qiang

机构信息

Pediatric Cardiac Surgical Centre, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 167A Beilishilu, Beijing, 100037, China.

出版信息

Pediatr Cardiol. 2017 Apr;38(4):643-649. doi: 10.1007/s00246-016-1561-x. Epub 2017 Jan 23.

Abstract

Although fenestration is used to improve the postoperative course of Fontan patients, the effect of fenestration on the extracardiac Fontan seems controversial especially at early postoperation. One hundred and eighty-three patients from January 2004 to June 2013 undergoing an extracardiac Fontan operation were retrospectively selected for this study. We divided the patients into low risk (93 patients) and high risk (90 patients) groups according to the risk factors recognized by previous studies and then compared the perioperative data between the nonfenestrated and fenestrated patients in each group. In both groups there was no significant difference in preoperative and operative data between the nonfenestrated and fenestrated patients. The postoperative blood oxygen saturation of fenestrated patients was significantly lower (p < 0.01) in each group. In the high risk group the chest tube volume (1153 mL vs. 1739 mL, p = 0.021) and chest tube duration (11.9 days vs. 17.0 days, p = 0.028) of fenestrated patients were lower comparing to nonfenestrated patients, while the chest tube volume and chest tube duration were similar between the nonfenestrated and fenestrated patients in the low risk group. The morbidity and mortality of nonfenestrated and fenestrated patients were similar in both groups (p > 0.05). Although fenestration was associated with lower postoperative oxygen saturation, fenestration showed better postoperative outcomes regarding the chest tube volume and duration for the high-risk patients. Considering the similar early postoperative outcomes of nonfenestrated and fenestrated patients in low risk group, our data indicate that fenestration for the high-risk patients should be performed.

摘要

尽管开窗术用于改善Fontan手术患者的术后病程,但开窗术对心外膜Fontan手术的影响似乎存在争议,尤其是在术后早期。本研究回顾性选取了2004年1月至2013年6月期间接受心外膜Fontan手术的183例患者。我们根据既往研究认可的危险因素将患者分为低风险组(93例患者)和高风险组(90例患者),然后比较每组未开窗和开窗患者的围手术期数据。两组中,未开窗和开窗患者的术前及手术数据均无显著差异。每组中,开窗患者的术后血氧饱和度显著更低(p<0.01)。在高风险组中,开窗患者的胸引量(1153 mL对1739 mL,p=0.021)和胸引管留置时间(11.9天对17.0天,p=0.028)低于未开窗患者,而低风险组中未开窗和开窗患者的胸引量及胸引管留置时间相似。两组中未开窗和开窗患者的发病率及死亡率相似(p>0.05)。尽管开窗术与术后较低的血氧饱和度相关,但对于高风险患者,开窗术在胸引量和胸引管留置时间方面显示出更好的术后结局。考虑到低风险组中未开窗和开窗患者相似的术后早期结局,我们的数据表明应针对高风险患者进行开窗术。

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