Cody D D, Flynn M J, Vickers D S
Division of Radiologic Physics and Engineering, Henry Ford Hospital, Detroit, Michigan 48202.
Med Phys. 1989 Sep-Oct;16(5):766-72. doi: 10.1118/1.596430.
A method for measuring the regional bone mineral density (rBMD) in human lumbar vertebral bodies using a series of contiguous computed tomography images, each 1 mm thick, is fully described. The technique has a sample volume of 0.004 cm3, a sample spacing of 0.8 X 0.8 X 1.0 mm, and results in a bone marrow radiation dose of 1.59 to 2.75 rads (0.016-0.028 Gy). The use of physical density (mg/cm3) is introduced and the measurement noise (0.7-1.3%), accuracy (2.7%), and serial precision (0.2%) have been evaluated in vitro using appropriate phantoms. The corresponding percentage errors for accuracy and precision relative to K2HPO4 concentration were 6.9% and 2.0%, respectively. A multiple region density measurement is described and evaluated.
本文详细介绍了一种利用一系列连续的计算机断层扫描图像（每层厚1毫米）测量人体腰椎椎体局部骨密度（rBMD）的方法。该技术的样本体积为0.004立方厘米，样本间距为0.8×0.8×1.0毫米，骨髓辐射剂量为1.59至2.75拉德（0.016 - 0.028戈瑞）。引入了物理密度（毫克/立方厘米）的概念，并使用合适的体模在体外评估了测量噪声（0.7 - 1.3%）、准确性（2.7%）和序列精度（0.2%）。相对于磷酸氢二钾浓度，准确性和精度的相应百分比误差分别为6.9%和2.0%。本文还描述并评估了多区域密度测量。
