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乙型肝炎病毒衣壳与基因组的核输入

Nuclear Import of Hepatitis B Virus Capsids and Genome.

作者信息

Gallucci Lara, Kann Michael

机构信息

Laboratoire de Microbiologie Fondamentale et Pathogénicité, University of Bordeaux, UMR 5234, F-33076 Bordeaux, France.

CNRS, Microbiologie Fondamentale et Pathogénicité, UMR 5234, F-33076 Bordeaux, France.

出版信息

Viruses. 2017 Jan 21;9(1):21. doi: 10.3390/v9010021.

DOI:10.3390/v9010021
PMID:28117723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5294990/
Abstract

Hepatitis B virus (HBV) is an enveloped pararetrovirus with a DNA genome, which is found in an up to 36 nm-measuring capsid. Replication of the genome occurs via an RNA intermediate, which is synthesized in the nucleus. The virus must have thus ways of transporting its DNA genome into this compartment. This review summarizes the data on hepatitis B virus genome transport and correlates the finding to those from other viruses.

摘要

乙型肝炎病毒（HBV）是一种具有DNA基因组的包膜副逆转录病毒，其衣壳直径可达36纳米。基因组通过在细胞核中合成的RNA中间体进行复制。因此，病毒必须有将其DNA基因组转运到这个区室的方式。这篇综述总结了关于乙型肝炎病毒基因组转运的数据，并将这些发现与其他病毒的发现进行了关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/964f4ff95409/viruses-09-00021-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/e7bea58906e3/viruses-09-00021-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/6a42c8bd8486/viruses-09-00021-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/e7fc4cd0ad23/viruses-09-00021-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/5af043f0a2d3/viruses-09-00021-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/c218c13c9c60/viruses-09-00021-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/964f4ff95409/viruses-09-00021-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/e7bea58906e3/viruses-09-00021-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/6a42c8bd8486/viruses-09-00021-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/e7fc4cd0ad23/viruses-09-00021-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/5af043f0a2d3/viruses-09-00021-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/c218c13c9c60/viruses-09-00021-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e3/5294990/964f4ff95409/viruses-09-00021-g006.jpg

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Importin β Can Bind Hepatitis B Virus Core Protein and Empty Core-Like Particles and Induce Structural Changes.输入蛋白β可结合乙型肝炎病毒核心蛋白及空壳样颗粒并诱导结构变化。
PLoS Pathog. 2016 Aug 12;12(8):e1005802. doi: 10.1371/journal.ppat.1005802. eCollection 2016 Aug.
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Overview of hepatitis B viral replication and genetic variability.
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Microorganisms. 2025 Jan 14;13(1):157. doi: 10.3390/microorganisms13010157.
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Channel width modulates the permeability of DNA origami-based nuclear pore mimics.通道宽度调节基于 DNA 折纸的核孔模拟物的通透性。
Sci Adv. 2024 Nov 15;10(46):eadq8773. doi: 10.1126/sciadv.adq8773. Epub 2024 Nov 13.
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