乙型肝炎病毒衣壳与基因组的核输入

Gallucci Lara, Kann Michael

Laboratoire de Microbiologie Fondamentale et Pathogénicité, University of Bordeaux, UMR 5234, F-33076 Bordeaux, France.

CNRS, Microbiologie Fondamentale et Pathogénicité, UMR 5234, F-33076 Bordeaux, France.

Viruses. 2017 Jan 21;9(1):21. doi: 10.3390/v9010021.

Hepatitis B virus (HBV) is an enveloped pararetrovirus with a DNA genome, which is found in an up to 36 nm-measuring capsid. Replication of the genome occurs via an RNA intermediate, which is synthesized in the nucleus. The virus must have thus ways of transporting its DNA genome into this compartment. This review summarizes the data on hepatitis B virus genome transport and correlates the finding to those from other viruses.

乙型肝炎病毒（HBV）是一种具有DNA基因组的包膜副逆转录病毒，其衣壳直径可达36纳米。基因组通过在细胞核中合成的RNA中间体进行复制。因此，病毒必须有将其DNA基因组转运到这个区室的方式。这篇综述总结了关于乙型肝炎病毒基因组转运的数据，并将这些发现与其他病毒的发现进行了关联。