Baraka A, Noueihid R, Sibai A N, Baroody M, Louis F, Hemady K
Department of Anesthesiology, American University, Beirut, Lebanon.
Middle East J Anaesthesiol. 1989 Jun;10(2):185-8.
Epidural meperidine was used to control autonomic hyperreflexia (AH) during cystoscopy and transuretheral sphincterotomy, in a quadriplegic patient who had chronic spinal cord transection at C6 level. Meperidine 100 mg diluted in 10 ml saline was injected in the epidural space at L3-L4 level. Within 10 minutes and throughout the surgical procedure, the blood pressure stabilized at 125/70-140/80 mmHg. Epidural meperidine produces selective blockade of the spinal opiate receptors and hence may block the nociceptive reflexes below the level of cord transection and prevent AH.
在一名C6水平慢性脊髓横断的四肢瘫痪患者的膀胱镜检查和经尿道括约肌切开术中，使用硬膜外哌替啶控制自主神经反射亢进（AH）。将100 mg哌替啶稀释于10 ml生理盐水中，在L3-L4水平注入硬膜外腔。在10分钟内及整个手术过程中，血压稳定在125/70 - 140/80 mmHg。硬膜外哌替啶可选择性阻断脊髓阿片受体，因此可能阻断脊髓横断水平以下的伤害性反射并预防AH。
