Eisenberg Tobias, Abdellatif Mahmoud, Zimmermann Andreas, Schroeder Sabrina, Pendl Tobias, Harger Alexandra, Stekovic Slaven, Schipke Julia, Magnes Christoph, Schmidt Albrecht, Ruckenstuhl Christoph, Dammbrueck Christopher, Gross Angelina S, Herbst Viktoria, Carmona-Gutierrez Didac, Pietrocola Federico, Pieber Thomas R, Sigrist Stephan J, Linke Wolfgang A, Mühlfeld Christian, Sadoshima Junichi, Dengjel Joern, Kiechl Stefan, Kroemer Guido, Sedej Simon, Madeo Frank
a Institute of Molecular Biosciences, NAWI Graz, University of Graz , Graz , Austria.
b BioTechMed Graz , Graz , Austria.
Autophagy. 2017 Apr 3;13(4):767-769. doi: 10.1080/15548627.2017.1280225. Epub 2017 Jan 24.
Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the development of cardiovascular disease. Dietary spermidine elicits cardioprotective effects in aged mice through enhancing cardiac autophagy and mitophagy. In salt-sensitive rats, spermidine supplementation also delays the development of hypertensive heart disease, coinciding with reduced arterial blood pressure. The high blood pressure-lowering effect likely results from improved global arginine bioavailability and protection from hypertension-associated renal damage. The polyamine spermidine is naturally present in human diets, though to a varying amount depending on food type and preparation. In humans, high dietary spermidine intake correlates with reduced blood pressure and decreased risk of cardiovascular disease and related death. Altogether, spermidine represents a cardio- and vascular-protective autophagy inducer that can be readily integrated in common diets.
心脏巨自噬/自噬功能的丧失会损害心脏功能，并且越来越多的证据表明自噬通量增加可能预防心血管疾病。因此，我们在衰老和高血压动物模型中测试了天然自噬诱导剂亚精胺的保护能力，这两种模型均代表心血管疾病发展的主要危险因素。饮食中的亚精胺通过增强心脏自噬和线粒体自噬，对老年小鼠产生心脏保护作用。在盐敏感大鼠中，补充亚精胺还可延缓高血压性心脏病的发展，同时降低动脉血压。降低高血压的作用可能源于整体精氨酸生物利用度的改善以及对高血压相关肾损伤的保护。多胺亚精胺天然存在于人类饮食中，但其含量因食物类型和制备方式而异。在人类中，高饮食亚精胺摄入量与血压降低以及心血管疾病和相关死亡风险降低相关。总之，亚精胺是一种可保护心脏和血管的自噬诱导剂，可轻松融入日常饮食。
