Iacob Daniela, Butnariu Angela, Leucuţa Daniel-Corneliu, Samaşca Gabriel, Deleanu Diana, Lupan Iulia
"Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, Department of Pediatrics, IIIrd Pediatric Clinic.
"Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, Department of Medical Informatics and Biostatistics.
Rom J Intern Med. 2017 Jun 1;55(2):69-74. doi: 10.1515/rjim-2017-0002.
Heart failure (HF) is characterized by neuroendocrine activation. The cardiac natriuretic hormones, including atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), together with their related pro-peptides (proANP and proBNP) represent a group of peptide hormones produced by the heart. A normal NT-proBNP level has a high negative predictive value for heart failure. The use of NT-proBNP testing is helpful in diagnosing acute HF in the emergency care setting, allowing an early and optimal treatment. The purpose of this study is to assess the prognostic value of NT-proBNP in heart failure in children younger than 3 years old and to establish whether it correlates with the NYHA/Ross functional class and left ventricle systolic function.
We enrolled 24 consecutive children with HF due to congenital heart diseases and dilated cardiomyopathy. The serum levels of NT-proBNP were measured, all patients underwent echocardiography and left ventricle ejection fraction was calculated.
The highest median value of NT-proBNP was recorded in patients with cyanotic heart diseases (248.0 fmol/mL), p = 0.610. NT-proBNP had a negative correlation with the ejection fraction of the left ventricle: Spearman's rank correlation coefficient was -0.165.
NT-proBNP levels correlate with the severity of HF in infants and small children younger than 3 years old with heart failure due to congenital heart diseases and dilated cardiomyopathy.
心力衰竭（HF）的特征是神经内分泌激活。心脏利钠肽激素，包括心房利钠肽（ANP）和脑利钠肽（BNP），以及它们相关的前体肽（proANP和proBNP）代表了一组由心脏产生的肽类激素。正常的NT-proBNP水平对心力衰竭具有较高的阴性预测价值。在急诊环境中使用NT-proBNP检测有助于诊断急性心力衰竭，从而实现早期和最佳治疗。本研究的目的是评估NT-proBNP在3岁以下儿童心力衰竭中的预后价值，并确定其是否与纽约心脏协会/罗斯功能分级和左心室收缩功能相关。
我们连续纳入了24例因先天性心脏病和扩张型心肌病导致心力衰竭的儿童。测量了NT-proBNP的血清水平，所有患者均接受了超声心动图检查并计算了左心室射血分数。
青紫型心脏病患者的NT-proBNP中位数最高（248.0 fmol/mL），p = 0.610。NT-proBNP与左心室射血分数呈负相关：Spearman等级相关系数为-0.165。
NT-proBNP水平与3岁以下因先天性心脏病和扩张型心肌病导致心力衰竭的婴幼儿心力衰竭严重程度相关。
