Feldon Michal, Farhadi Payam Noroozi, Brunner Hermine I, Itert Lukasz, Goldberg Bob, Faiq Abdullah, Wilkerson Jesse, Rose Kathryn M, Rider Lisa G, Miller Frederick W, Giannini Edward H
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland.
Arthritis Care Res (Hoboken). 2017 Nov;69(11):1743-1750. doi: 10.1002/acr.23198. Epub 2017 Sep 21.
Extensive studies on health-related quality of life (HRQoL) in idiopathic inflammatory myopathies (IIMs) are lacking. Our objective was to document HRQoL and to identify factors associated with a reduced HRQoL in patients with IIM.
A total of 1,715 patients (median age 49.9 years, 70% female, 87% white) who met probable or definite Bohan and Peter criteria or Griggs criteria for myositis were included from the Myovision registry. HRQoL was ascertained using the Short Form 12 (SF-12) health survey questionnaire. HRQoL physical component summary (PCS) and mental component summary (MCS) scores in relation to different patient and disease characteristics were compared to scores from matched normative data from the US general population and rheumatoid arthritis (RA) patients. Bivariate and multiple linear regression analyses were performed to assess the association between HRQoL and patient and disease parameters.
The mean SF-12 summary scores were significantly lower in IIM patients than in the normative and RA populations. A diagnosis of inclusion body myositis, older age, patient-reported negative effect of disease on work, presence of another co-occurring autoimmune disease, polypharmacy, and IIM-associated lung disease and joint involvement were significantly associated with lower PCS scores. Lower MCS scores were associated with joint involvement and a negative effect of disease on work.
In this large study of patient-reported outcomes in IIM, an association was found between multiple disease characteristics and reduced HRQoL, mostly in the physical domain. In the US, the HRQoL of IIM patients was found to be lower than that of the general population and RA patients.
目前缺乏关于特发性炎性肌病（IIM）患者健康相关生活质量（HRQoL）的广泛研究。我们的目的是记录IIM患者的HRQoL，并确定与HRQoL降低相关的因素。
从Myovision注册中心纳入了总共1715例符合可能或明确的Bohan和Peter标准或Griggs肌炎标准的患者（中位年龄49.9岁，70%为女性，87%为白人）。使用简短健康调查问卷12项（SF-12）确定HRQoL。将与不同患者和疾病特征相关的HRQoL身体成分总结（PCS）和精神成分总结（MCS）得分与来自美国普通人群和类风湿关节炎（RA）患者的匹配标准数据得分进行比较。进行双变量和多元线性回归分析以评估HRQoL与患者及疾病参数之间的关联。
IIM患者的平均SF-12总结得分显著低于标准人群和RA患者。包涵体肌炎诊断、年龄较大、患者报告疾病对工作有负面影响、存在另一种同时发生的自身免疫性疾病、联合用药、IIM相关的肺部疾病和关节受累与较低的PCS得分显著相关。较低的MCS得分与关节受累和疾病对工作的负面影响相关。
在这项关于IIM患者报告结局的大型研究中，发现多种疾病特征与HRQoL降低之间存在关联，主要在身体领域。在美国，发现IIM患者的HRQoL低于普通人群和RA患者。
