Fry C H, Miller D J, Harding D P, Harrison S M
Dept of Physiology, St. Thomas' Hospital Medical School (UMDS), London, UK.
Mol Cell Biochem. 1989 Sep 7;89(2):127-33. doi: 10.1007/BF00220764.
The possible contribution of mitochondrial Ca2+ accumulation and release to contractile phenomena has been investigated. Two intracellular fractions of Ca2+ sequestration can be identified in cardiac myocytes, one ascribed to mitochondria. Two modes of Ca2+ transport exist within the mitochondrial fraction, one dependent upon mitochondrial respiration and the other upon extramitochondrial [Na+]. Experiments with trabeculae show that under appropriate conditions, the rate of relaxation and the amount of tension developed is dependent on these two modes of Ca2+ transport. A model is presented quantifying the contribution of the mitochondria to relaxation.
