Golbe L I, Davis P H, Lepore F E
Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903.
Mov Disord. 1989;4(4):297-302. doi: 10.1002/mds.870040402.
We systematically videotaped eyelid movements in a community-based series of 38 patients with progressive supranuclear palsy (PSP). Ten patients (26%) had blepharospasm, "apraxia" of lid opening and/or "apraxia" of lid closing. These patients as a group had more severe upgaze paresis but no greater disease duration than the patients without supranuclear lid dysfunction. Patients used a variety of synkinetic movements to overcome lid-movement abnormalities. One patient displayed "slow blinks," a phenomenon not previously described in PSP. Blink rate in PSP, 3.0/min, was markedly lower than that in patients with Parkinson's disease (PD), 12.5/min, and patients with PSP but not PD increased their blink rate during command versional eye movements.
我们对以社区为基础的38例进行性核上性麻痹（PSP）患者的眼睑运动进行了系统录像。10例患者（26%）出现眼睑痉挛、睁眼“失用症”和/或闭眼“失用症”。与没有核上性眼睑功能障碍的患者相比，这些患者作为一个群体有更严重的上视麻痹，但病程并无更长。患者使用多种联带运动来克服眼睑运动异常。1例患者表现出“缓慢眨眼”，这是PSP中以前未描述过的现象。PSP患者眨眼频率为3.0次/分钟，明显低于帕金森病（PD）患者的12.5次/分钟，且PSP但无PD的患者在命令性眼球转向运动期间眨眼频率增加。
