Jain R, Ramanan S V
Arch Intern Med. 1978 Nov;138(11):1726. doi: 10.1001/archinte.138.11.1726.
A patient with acute lymphocytic leukemia developed acute pancreatitis during induction therapy with corticosteroids and asparaginase. Postmortem examination showed changes consistent with hemorrhagic pancreatitis and fat necrosis over the pancreas and omentum. Corticosteroids were thought to be responsible for pancreatitis in this patient since "hemorrhagic pancreatitis" has not been previously described with asparaginase. We recommend careful follow-up of serum and urinary amylase values in patients receiving induction therapy with these agents.
一名急性淋巴细胞白血病患者在接受皮质类固醇和天冬酰胺酶诱导治疗期间发生了急性胰腺炎。尸检显示胰腺和大网膜出现了与出血性胰腺炎和脂肪坏死一致的变化。皮质类固醇被认为是该患者胰腺炎的病因，因为此前尚未有使用天冬酰胺酶导致“出血性胰腺炎”的描述。我们建议对接受这些药物诱导治疗的患者密切随访血清和尿淀粉酶值。
