Chabasse D, De Gentile L, Bouchara J P
Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Régional, Angers, France.
Mycopathologia. 1989 Jun;106(3):171-7. doi: 10.1007/BF00443059.
In order to appreciate the pathogenicity of several geophilic Chrysosporium species (including Anixiopsis stercoraria, Chrysosporium keratinophilum, C. tropicum, C. pannorum, C. state Arthroderma curreyi, C. state of A. multifidum, and C. state of A. tuberculatum), the authors have realized two series of experimental infestations. Inoculation of these fungi on the back of guinea pigs produced rare erythematous scaling lesions which spontaneously disappeared 3-5 weeks later. No real hair invasion was observed. In white mice, eight weeks after intraperitoneal inoculation, granulomas with necrotic center were observed in the peritoneal tissue with C. keratinophilum, C. tropicum, C. state of A. curreyi and C. state A. tuberculatum. Conidia were often intact in necrotic centers and retrocultures were positive. With C. state of A. curreyi, spherical spores associated with rare budding cells were noted. The pathogenic role of these keratinophilic fungi is uncertain. However, their ability to remain viable for several weeks in skin and peritoneal tissue indicates that they could become pathogen in certain circumstances.
为了了解几种嗜土金孢子菌属物种（包括粪生拟阿尼西霉、嗜角质金孢子菌、热带金孢子菌、泛生金孢子菌、柯里节皮菌状态的金孢子菌、多裂拟阿尼西霉状态的金孢子菌以及结核拟阿尼西霉状态的金孢子菌）的致病性，作者进行了两个系列的实验性感染。将这些真菌接种到豚鼠背部产生了罕见的红斑鳞屑性病变，这些病变在3 - 5周后自行消失。未观察到真正的毛发侵犯。在白色小鼠中，腹腔接种八周后，在腹膜组织中观察到嗜角质金孢子菌、热带金孢子菌、柯里节皮菌状态的金孢子菌以及结核拟阿尼西霉状态的金孢子菌感染后出现了带有坏死中心的肉芽肿。分生孢子在坏死中心通常保持完整，再培养结果为阳性。对于柯里节皮菌状态的金孢子菌，观察到了与罕见芽生细胞相关的球形孢子。这些嗜角质真菌的致病作用尚不确定。然而，它们在皮肤和腹膜组织中能够存活数周的能力表明，在某些情况下它们可能会成为病原体。
