使用频繁安装的0.05%环孢素滴眼液治疗春季角结膜炎性盾形溃疡。
Vernal shield ulcers treated with frequently installed topical cyclosporine 0.05% eyedrops.
作者信息
Westland Tim, Patryn Eliza K, Nieuwendaal Carla P, van der Meulen Ivanka J E, Mourits Maarten P, Lapid-Gortzak Ruth
机构信息
Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.
Department of Ophthalmology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
出版信息
Int Ophthalmol. 2018 Feb;38(1):363-368. doi: 10.1007/s10792-016-0424-z. Epub 2017 Jan 24.
PURPOSE
To report on the beneficial results of an intense regimen of 0.05% cyclosporine eye drops, eight times a day in patients with therapy resistant vernal shield ulcers.
METHODS
Case cohort of four eyes of three male children with vernal keratoconjunctivitis complicated by shield ulcers, who were treated with frequent cyclosporine 0.05% eye drops and observed for up to 5 years.
RESULTS
Quick resolution of the shield ulcers and complete re-epithelialization within 14-25 days was observed after adding intensive treatment with cyclosporine 0.05% to regular anti-inflammatory, histamine blocking, and surgical therapy. In one patient, additional scraping of the bottom of the ulcer was needed.
CONCLUSIONS
In patients with vernal shield ulcers, frequent installation of low-concentration cyclosporine eye drops seems to have a promising therapeutical value.
目的
报告0.05%环孢素滴眼液每日八次的强化治疗方案对治疗抵抗性春季角结膜下溃疡患者的有益效果。
方法
对三名患有春季角结膜炎并发角结膜下溃疡的男性儿童的四只眼睛进行病例队列研究，这些患儿接受频繁使用0.05%环孢素滴眼液治疗，并观察长达5年。
结果
在常规抗炎、组胺阻断和手术治疗基础上加用0.05%环孢素强化治疗后，观察到角结膜下溃疡在14 - 25天内迅速消退且完全重新上皮化。一名患者需要额外刮除溃疡底部。
结论
对于春季角结膜下溃疡患者，频繁滴注低浓度环孢素滴眼液似乎具有良好的治疗价值。
Zotero 插件