Greenhawt Matthew
Allergy Asthma Proc. 2017 Mar 24;38(2):92-97. doi: 10.2500/aap.2017.38.4037. Epub 2017 Jan 24.
Peanut allergy is a significant public health problem without proven treatment or cure at present. In 2000, the American Academy of Pediatrics recommended that solid-food introduction be delayed in infants at high risk, including peanut introduction, until age 3 years. In 2008, the American Academy of Pediatrics revised these recommendations based on limited evidence of benefit and, instead, recommended solid-food introduction not be delayed past 4-6 months of life. In 2015, the Learning Early About Peanut Allergy study showed that early peanut introduction (between 4 and 11 months of life) was associated with a significant absolute and relative risk reduction in the development of peanut allergy compared with delayed introduction. Based on these findings, the National Institutes of Allergy and Infectious Diseases sponsored an expert panel to create an addendum to the 2010 Food Allergy Guidelines that specifically focuses on peanut allergy prevention. The addendum recommends that children with severe eczema, egg allergy, or both have peanut introduced as early as 4-6 months of life, after assessment by a trained allergy specialist. For children with mild-to-moderate eczema, peanut can be introduced at ∼6 months, without the need for specialist evaluation. For children with no eczema, peanut can be introduced in accordance with family and cultural preferences, without the need for specialist evaluation. Adherence to these clinical practice recommendations can help potentially reduce the number of cases of peanut allergy per year. However, this can only be accomplished with the cooperation of parents and health care providers who adhere to these recommendations.
花生过敏是一个重大的公共卫生问题,目前尚无经过验证的治疗方法或治愈手段。2000年,美国儿科学会建议,对于包括花生在内的高危婴儿,应推迟引入固体食物,直至3岁。2008年,美国儿科学会基于有限的获益证据修订了这些建议,转而建议固体食物的引入不应推迟至4至6个月龄之后。2015年,“早期了解花生过敏”研究表明,与延迟引入相比,早期引入花生(在4至11个月龄之间)与花生过敏发生的绝对风险和相对风险显著降低相关。基于这些发现,美国国立过敏与传染病研究所赞助了一个专家小组,以制定2010年《食物过敏指南》的附录,该附录专门关注花生过敏的预防。该附录建议,患有严重湿疹、鸡蛋过敏或两者皆有的儿童,在经过训练有素的过敏专科医生评估后,应早在4至6个月龄时引入花生。对于患有轻至中度湿疹的儿童,可在约6个月龄时引入花生,无需专科评估。对于没有湿疹的儿童,可根据家庭和文化偏好引入花生,无需专科评估。遵守这些临床实践建议可能有助于每年减少花生过敏的病例数。然而,这只有在家长和医疗服务提供者遵守这些建议的合作下才能实现。