School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Sci Rep. 2017 Jan 25;7:41140. doi: 10.1038/srep41140.
Rs1344706 in the the zinc finger protein 804A (ZNF804A) gene has been identified to be associated with schizophrenia and bipolar disorder (BD) in Europeans. However, whether rs1344706 is associated with schizophrenia in Chinese populations remains inconclusive; furthermore, the association between rs1344706 and BD in Chinese populations has been rarely explored. To explore the association between rs1344706 and schizophrenia/BD in Chinese populations, we genotyped rs1344706 among 1128 Chinese subjects (537 patients with BD and 591 controls) and found that rs1344706 showed marginal allelic association with BD (P = 0.028) with T-allele being more prevalent in cases than that in controls (OR = 1.19, 95% CI 1.03-1.37). Meta-analysis of rs1344706 by pooling all available data showed that rs1344706 was significantly associated with BD (P = 0.001). Besides, positive association of rs1344706 with schizophrenia was observed in Northern Chinese (P = 0.005). Furthermore, ZNF804A is highly expressed in human and mouse brains, especially in prenatal stage.
锌指蛋白 804A（ZNF804A）基因中的 rs1344706 已被确定与欧洲人群中的精神分裂症和双相情感障碍（BD）有关。然而，rs1344706 是否与中国人群中的精神分裂症有关仍不确定；此外，rs1344706 与中国人群中的 BD 之间的关联很少被探索。为了探讨 rs1344706 与中国人群中精神分裂症/BD 的关联，我们对 1128 名中国受试者（537 名 BD 患者和 591 名对照）进行了 rs1344706 基因分型，发现 rs1344706 与 BD 呈边缘等位基因关联（P=0.028），与对照组相比，T 等位基因在病例中更为常见（OR=1.19，95%CI 1.03-1.37）。通过合并所有可用数据对 rs1344706 进行的荟萃分析表明，rs1344706 与 BD 显著相关（P=0.001）。此外，在中国北方人群中观察到 rs1344706 与精神分裂症呈正相关（P=0.005）。此外，ZNF804A 在人和小鼠大脑中高度表达，特别是在产前阶段。
