典型阿尔茨海默病的遗传学研究。

Genetic studies of typical Alzheimer's disease.

作者信息

Mohs R C, Greenberg D A, Silverman J M

机构信息

Psychiatry Service, Veterans Administration Medical Center, Bronx, NY 10468.

出版信息

Neurobiol Aging. 1989 Sep-Oct;10(5):438-9; discussion 446-8. doi: 10.1016/0197-4580(89)90089-4.

DOI:10.1016/0197-4580(89)90089-4

PMID:2812205

Abstract

Typical, late-onset Alzheimer's disease is familial but shows no clear Mendelian pattern of inheritance. Strategies that could help to reveal its genetics are: 1) identification of genetically homogeneous phenotypes, 2) identification of early or alternate manifestations of AD gene expression in relatives, and 3) use of small multiplex families with cases of typical AD for linkage studies.

摘要

典型的晚发性阿尔茨海默病具有家族性，但没有明确的孟德尔遗传模式。有助于揭示其遗传学特征的策略有：1）识别基因同质的表型，2）识别亲属中AD基因表达的早期或交替表现，以及3）利用患有典型AD的小型核心家系进行连锁研究。