Chuang Tzu-Yun, Yeh Mei-Ling, Chung Yu-Chu
Department of Nursing, Taipei Veterans General Hospital, No. 201, Selection 2, Shi-Pai Road, Taipei City 11217, Taiwan, ROC.
Graduate Institute of Integration of Traditional Chinese Medicine with Western Nursing, National Taipei University of Nursing and Health Sciences, No. 365, Ming-Te Road, Taipei City 11219, Taiwan, ROC.
Int J Nurs Stud. 2017 Apr;69:25-33. doi: 10.1016/j.ijnurstu.2017.01.004. Epub 2017 Jan 19.
Non-Hodgkin's lymphoma is a heterogeneous group of lymphoproliferative malignancies. Chemotherapy can improve patient survival rates, yet it is also associated with many adverse physical and psychosocial effects. It is suggested that qigong practices may be used to reduce patient distress and side effects.
To evaluate the effects of Chan-Chuang qigong on fatigue, complete blood cells, sleep quality, and quality of life for patients with non-Hodgkin lymphoma who had undergone the first course of chemotherapy.
A randomized controlled study.
An oncology ward of medical centre in northern Taiwan.
Fifty participants in each of the two groups.
Participants were randomly assigned to either the qigong group (n=50) that received a 21-day Chan-Chuang qigong programme, or the control group (n=50). The primary outcome was fatigue measured by Brief Fatigue Inventory. The secondary outcomes were complete blood cell counts, sleep quality measured by Verran and Snyder-Halpern Sleep Scale, and quality of life measured by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire.
After 21 days of intervention, the results obtained from ninety six participants were analysed. Participants in the qigong group exhibited decreased fatigue intensity and fatigue interference from 5.49 (SD=1.02) and 5.53 (SD=1.27) to 0.37 (SD=1.39) and 0.20 (SD=1.93), respectively. Generalized estimating equations analyses revealed that the qigong group, when compared to the control group, had significant improvement in fatigue intensity and fatigue interference over time (β=-1.04, 95% confidence interval [CI] from -1.59 to -0.48, p<0.001; and β=-1.22, 95% CI from -1.86 to -0.59, p<0.001, respectively). There was a significant between-group difference in the improvement in white blood cell counts (t=5.14, p<0.001), hemoglobin levels (t=3.17, p=0.002), and sleep quality (t=17.73, p<0.001), but not in platelet counts (p=0.05). With regard to quality of life, the scores of the qigong group improved in all subscales and all symptom items when compared to that of the control group. No adverse effects were observed in the qigong group.
The findings of this study indicate that the 21-day Chan- Chuang qigong can reduce fatigue intensity and fatigue interference, and improved white blood cell counts, haemoglobin levels, sleep quality, and quality of life for patients with non-Hodgkin lymphoma who had undergone the first course of chemotherapy. Further studies involving a prolonged extended intervention period and follow-up are necessary for determining the long-term effect of qigong exercise.
非霍奇金淋巴瘤是一组异质性的淋巴增殖性恶性肿瘤。化疗可提高患者生存率，但也会带来许多不良的身体和心理社会影响。有人提出气功练习可能有助于减轻患者痛苦和副作用。
评估禅创气功对接受首个疗程化疗的非霍奇金淋巴瘤患者的疲劳、全血细胞、睡眠质量和生活质量的影响。
一项随机对照研究。
台湾北部一家医疗中心的肿瘤科病房。
两组各50名参与者。
参与者被随机分配到接受为期21天禅创气功训练的气功组（n = 50）或对照组（n = 50）。主要结局是通过简明疲劳量表测量的疲劳。次要结局是全血细胞计数、通过Verran和Snyder-Halpern睡眠量表测量的睡眠质量，以及通过欧洲癌症研究与治疗组织生活质量问卷测量的生活质量。
经过21天的干预后，对96名参与者的结果进行了分析。气功组参与者的疲劳强度和疲劳干扰分别从5.49（标准差 = 1.02）和5.53（标准差 = 1.27）降至0.37（标准差 = 1.39）和0.20（标准差 = 1.93）。广义估计方程分析显示，与对照组相比，气功组随时间推移在疲劳强度和疲劳干扰方面有显著改善（β = -1.04，95%置信区间[CI]从 -1.59至 -0.48，p < 0.001；β = -1.22，95%CI从 -1.86至 -0.59，p < 0.001）。白细胞计数（t = 5.14，p < 0.001）、血红蛋白水平（t = 3.17，p = 0.002）和睡眠质量（t = 17.73，p < 0.001）的改善在组间存在显著差异，但血小板计数方面无差异（p = 0.05）。在生活质量方面，与对照组相比，气功组在所有子量表和所有症状项目上的得分均有所提高。气功组未观察到不良反应。
本研究结果表明，为期21天的禅创气功可降低接受首个疗程化疗的非霍奇金淋巴瘤患者的疲劳强度和疲劳干扰，并改善白细胞计数、血红蛋白水平、睡眠质量和生活质量。需要进一步开展涉及更长干预期和随访的研究，以确定气功锻炼的长期效果。
