Modai I, Apter A, Meltzer M, Tyano S, Walevski A, Jerushalmy Z
Gehah Psychiatric Hospital, Petah Tiqva, Israel.
Neuropsychobiology. 1989;21(1):9-13. doi: 10.1159/000118543.
Thirty-four adolescent psychiatric inpatients were studied in order to find out whether there is a correlation between serotonin platelet uptake (SPU), suicidality and aggression. The patients were divided into four main diagnostic groups according to clinical data: borderline personality disorder, affective disorder (unipolar) including schizoaffective disorder, schizophrenia and 'others'. These patients were also characterized by the quantitative symptoms profile from K-SADS scale (Children's Version of the Schedule of Affective Disorders and Schizophrenia) and by their behavior: aggression, suicide attempts and violent suicide attempts. In the schizophrenic group, a correlation was found between low Vmax values of SPU and aggressive behavior (p less than 0.05). In addition, in the 'other' group a correlation was found between low Vmax values of SPU and conduct disorder (p less than 0.05). On the other hand, in 'other' patients a correlation was found between low Km values of SPU and violent suicide attempt (p less than 0.05). It is noteworthy that the lowest (20-35%) Vmax values of SPU were found in the patients of the affective group as compared to values of the three other diagnostic groups. These findings are similar to those concerning unipolar depressive adults. It is assumed that there are less binding sites for serotonin on platelets of depressive adolescents than was suggested for depressive adults.
对34名青少年精神病住院患者进行了研究，以确定血清素血小板摄取（SPU）、自杀倾向和攻击性之间是否存在相关性。根据临床数据，将患者分为四个主要诊断组：边缘性人格障碍、情感障碍（单相）包括分裂情感性障碍、精神分裂症和“其他”。这些患者还通过K-SADS量表（情感障碍和精神分裂症儿童版）的定量症状概况以及他们的行为来表征：攻击性、自杀未遂和暴力自杀未遂。在精神分裂症组中，发现SPU的低Vmax值与攻击行为之间存在相关性（p<0.05）。此外，在“其他”组中，发现SPU的低Vmax值与品行障碍之间存在相关性（p<0.05）。另一方面，在“其他”患者中，发现SPU的低Km值与暴力自杀未遂之间存在相关性（p<0.05）。值得注意的是，与其他三个诊断组的值相比，情感组患者的SPU的Vmax值最低（20-35%）。这些发现与关于单相抑郁成年人的发现相似。据推测，抑郁青少年血小板上血清素的结合位点比抑郁成年人的要少。
