Okazaki Ryo
Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.
Clin Calcium. 2017;27(2):263-271.
Bisphosphonates have been explored possible combination and/or sequential use with other anti-osteoporotic medications including PTH. Besides with vitamin D(metabolites), combination treatment had been uncommon mainly because there had not been enough anti-fracture evidence. PTH, which can only be used for a certain period over lifetime, requires other anti-osteoporotic medications after and/or before its use. Bisphosphonates have been tried with PTH in various sequential and/or combination ways. Various combination and/or sequential therapy using bisphosphonates will be reviewed in this article.
双膦酸盐已被探索与包括甲状旁腺激素（PTH）在内的其他抗骨质疏松药物联合使用和/或序贯使用。除了与维生素D（代谢物）联合外，联合治疗并不常见，主要是因为缺乏足够的抗骨折证据。PTH在一生中只能使用一定时间，在其使用前后需要其他抗骨质疏松药物。双膦酸盐已尝试与PTH以各种序贯和/或联合方式使用。本文将综述使用双膦酸盐的各种联合和/或序贯疗法。
