Moy S, Opfer-Gehrking T L, Proper C J, Low P A
Department of Neurology, Mayo Clinic, Rochester, MN 55905.
Neurology. 1989 Nov;39(11):1490-2. doi: 10.1212/wnl.39.11.1490.
Limb dependency activates the venoarteriolar reflex (VAR), resulting in reflex vasoconstriction (RV). Since others have reported the VAR to fail in diabetic neuropathy, we examined the reliability of this test in detecting sympathetic failure in diabetic and other neuropathies. We studied 40 controls, 49 diabetic subjects, and 29 patients with other neuropathies. The mean RV was greater in controls than in diabetics or other neuropathies, but there were marked overlaps among groups. We conclude that the VAR, while impaired in the neuropathies, is of little value as a clinical test and is a poorer test of autonomic function than the quantitative sudomotor axon reflex test or heart rate responses to deep breathing or the Valsalva maneuver.
肢体依赖会激活静脉小动脉反射（VAR），导致反射性血管收缩（RV）。由于其他人报告称糖尿病性神经病变患者的VAR不起作用，我们研究了该测试在检测糖尿病及其他神经病变患者交感神经功能衰竭方面的可靠性。我们研究了40名对照组、49名糖尿病患者和29名患有其他神经病变的患者。对照组的平均RV大于糖尿病患者或患有其他神经病变的患者，但各组之间存在明显重叠。我们得出结论，虽然神经病变患者的VAR受损，但作为一项临床测试价值不大，并且与定量汗腺轴突反射测试、深呼吸或瓦尔萨尔瓦动作时的心率反应相比，它对自主神经功能的测试效果更差。
