Sun Fenglei, Sun Xintang, Du Xiaolong, Xing Hongshun, Yang Bin
Department of Neurosurgery, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China.
Department of Food and Pharmaceutical Science and Technology, Shandong Vocational Animal Science and Veterinary College, Weifang, Shandong 261061, P.R. China.
Oncol Lett. 2017 Jan;13(1):250-252. doi: 10.3892/ol.2016.5418. Epub 2016 Nov 22.
Factors related to endocrine changes and hormone substitution treatment during pre- and post-operation periods in craniopharyngioma cases were examined. Twenty patients who underwent tumor resection from January 2012 to January 2015 were included in the study. We monitored factors related to endocrine changes and hormone substitution treatment during pre- and post-operation periods. Blood thyroid-stimulating hormone, triiodothyronine, thyroxine, prolactin, follicle-stimulating hormone, luteinizing hormone and cortisol levels were measured in the patients. Urinary volume and urine specific gravity were also measured before and after the operation. After the operation, we observed diabetes insipidus and a decrease in TSH and gonadal hormone levels more frequently compared to pre-operation. However, incidence of high prolactin was markedly reduced following surgery. The number of hypothyroidism cases before and after surgery had no statistical significance. In conclusion, surgery for craniopharyngioma aggravated endocrine dysfunction. Craniotomy and total tumor resection had considerable effects on the endocrine system. Routine hormone therapy as an alternative treatment was necessary after operation. Alternative treatment of adrenal cortex hormones reduced the incidence on low blood cortisol.
研究了颅咽管瘤患者术前和术后内分泌变化及激素替代治疗的相关因素。本研究纳入了2012年1月至2015年1月期间接受肿瘤切除术的20例患者。我们监测了术前和术后内分泌变化及激素替代治疗的相关因素。测定了患者血液中的促甲状腺激素、三碘甲状腺原氨酸、甲状腺素、催乳素、促卵泡激素、黄体生成素和皮质醇水平。还在手术前后测量了尿量和尿比重。术后，与术前相比，我们更频繁地观察到尿崩症以及促甲状腺激素和性腺激素水平下降。然而，术后高催乳素血症的发生率明显降低。手术前后甲状腺功能减退病例数无统计学意义。总之，颅咽管瘤手术加重了内分泌功能障碍。开颅手术和肿瘤全切除对内分泌系统有相当大的影响。术后常规激素治疗作为替代治疗是必要的。肾上腺皮质激素替代治疗降低了低血皮质醇的发生率。
